Quins fly half Rory Clegg has been recalled from Championship side LEeds Carnegie to start Sunday's final LV= Cup group clash with the Ospreys.
Clegg is currently on loan at Headingly on a dual registration deal and returns for this fixture having played a key role for the Yorkshiremen against Jersey, Leinster ‘A’ and Bristol.
With Tom Casson picking up a minor knock in last week’s victory over London Welsh, Ben Botica moves to inside centre, while Ross Chisholm starts at full back having made his comeback from injury last week.
There are no changes to the forward pack, with “LV= Breakthrough Player of the year” nominees Joe Trayfoot and captain Luke Wallace combining with Tom Guest in the back row.
Among the replacements, James Johnston and Maurie Fa’asavalu are named in the absence of Kyle Sinckler and Jack Clifford to the England U20s.
Quins need a draw or better as they go in search of a home semi-final in the knockout stages.
Harlequins Team: 15. Ross Chisholm, 14. Seb Stegmann, 13. Matt Hopper, 12. Ben Botica, 11. Sam Smith, 10. Rory Clegg, 9. Karl Dickson; 1. Mark Lambert. 2. Dave Ward. 3. Will Collier. 4. Sam Twomey. 5. Charlie Matthews, 6. Joe Trayfoot, 7. Luke Wallace (C), 8. Tom Guest.
Replacements: 16. Harry Allen, 17. Darryl Marfo, 18. James Johnston, 19. Charlie Walker, 20. Maurie Fa’asavalu, 21. Jordan Burns, 22. Louis Grimoldby, 23. Ollie Lindsay-Hague.